3D Printable Device for Automated Operant Conditioning in the Mouse
Por um escritor misterioso
Descrição
Operant conditioning (OC) is a classical paradigm and a standard technique used in experimental psychology in which animals learn to perform an action to achieve a reward. By using this paradigm, it is possible to extract learning curves and measure accurately reaction times (RTs). Both these measurements are proxy of cognitive capabilities and can be used to evaluate the effectiveness of therapeutic interventions in mouse models of disease. Here, we describe a fully 3D printable device that is able to perform OC on freely moving mice, while performing real-time tracking of the animal position. We successfully trained six mice, showing stereotyped learning curves that are highly reproducible across mice and reaching >70% of accuracy after 2 d of conditioning. Different products for OC are commercially available, though most of them do not provide customizable features and are relatively expensive. This data demonstrate that this system is a valuable alternative to available state-of-the-art commercial devices, representing a good balance between performance, cost, and versatility in its use.
PDF) 3D Printable Device for Automated Operant Conditioning in the Mouse
Frontiers Open Source Tools for Temporally Controlled Rodent Behavior Suitable for Electrophysiology and Optogenetic Manipulations
(PDF) Automated Operant Conditioning in the Mouse Home Cage
Evaluating Skilled Prehension in Mice Using an Auto-Trainer
Open Source Toolkit
Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages
PDF) 3D Printable Device for Automated Operant Conditioning in the Mouse
A low-cost open-source 5-choice operant box system optimized for electrophysiology and optophysiology in mice
Schematic representation of the odor port and the olfactometer. (A)
Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages
Actuated two-axis rodent manipulandum design and assembly. a-d
Automated and rapid self-report of nociception in transgenic mice
An open-source device for measuring food intake and operant behavior in rodent home-cages
de
por adulto (o preço varia de acordo com o tamanho do grupo)
